The triggering of NK cell cytotoxicity against the absence of killing activity is determined by a delicate balance between activating and inhibitory signals delivered by many families of cell surface receptors. This process is not totally understood and is under ongoing investigation.9 Furthermore, our finding of increased percentage of total T cells and T helper cells in the SCI group as compared to controls is consistent with the understanding that NK cells do influence cells of the adaptive immune system including T cells.9 For example, in human autoimmune disease, it has been suggested that NK cells trigger autoreactive T cells.9 Our finding of increase in percent T cells and T helper cells may be a compensatory change related to reduced numbers of NK cells. The mechanism and details of interaction between the innate and adaptive immune have yet to be fully worked out..
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